RT Journal Article SR Electronic T1 DWI for Monitoring the Acute Response of Malignant Gliomas to Photodynamic Therapy JF American Journal of Neuroradiology JO Am. J. Neuroradiol. FD American Society of Neuroradiology SP 2045 OP 2051 DO 10.3174/ajnr.A6300 VO 40 IS 12 A1 Y. Fujita A1 T. Sasayama A1 K. Tanaka A1 K. Kyotani A1 H. Nagashima A1 M. Kohta A1 H. Kimura A1 A. Fujita A1 E. Kohmura YR 2019 UL http://www.ajnr.org/content/40/12/2045.abstract AB BACKGROUND AND PURPOSE: Photodynamic therapy is a novel treatment that provides effective local control, but little is known about photodynamic therapy–induced changes on MR imaging. The aim of this study was to assess the utility of DWI and ADC in monitoring the response of malignant gliomas to photodynamic therapy.MATERIALS AND METHODS: Time-dependent changes in DWI and ADC values after photodynamic therapy were analyzed in a group that received photodynamic therapy in comparison with a group that did not.RESULTS: Twenty-four patients were enrolled (photodynamic therapy, n = 14; non-photodynamic therapy, n = 10). In all patients who received photodynamic therapy, linear high signals on DWI in the irradiated area were detected adjacent to the resection cavity and were 5–7 mm in depth from 1 day posttreatment and disappeared in about 30 days without any neurologic deterioration. The non-photodynamic therapy group did not show this change. The photodynamic therapy group had significantly lower ADC values from 1 day posttreatment (P < .001), which increased steadily and disappeared by 30 days. There was no decline or time-dependent change in ADC values in the non-photodynamic therapy group.CONCLUSIONS: The acute response of malignant gliomas to photodynamic therapy was detected as linear high signals on DWI and as a decrease in ADC values. These findings were asymptomatic and transient. Although the photodynamic therapy–induced acute response on MR imaging disappeared after approximately 30 days, it may be helpful for confirming the photodynamic therapy–irradiated area.CEcontrast-enhancedPDTphotodynamic therapy