TY - JOUR T1 - White Matter Injury and Structural Anomalies in Infants with Prenatal Opioid Exposure JF - American Journal of Neuroradiology JO - Am. J. Neuroradiol. SP - 2161 LP - 2165 DO - 10.3174/ajnr.A6282 VL - 40 IS - 12 AU - S.L. Merhar AU - N.A. Parikh AU - A. Braimah AU - B.B. Poindexter AU - J. Tkach AU - B. Kline-Fath Y1 - 2019/12/01 UR - http://www.ajnr.org/content/40/12/2161.abstract N2 - SUMMARY: Previous studies have not found structural injury or brain malformations in infants and children with prenatal opioid exposure. As part of an ongoing study evaluating neuroimaging in infants with prenatal opioid exposure, we reviewed structural brain MR imaging in 20 term infants with prenatal opioid exposure and 20 term controls at 4–8 weeks of age. We found that 8 of the 20 opioid-exposed infants had punctate white matter lesions or white matter signal abnormality on structural MR imaging, and 2 of the opioid-exposed infants had a septopreoptic fusion anomaly. No controls had white matter injury or structural malformations. Our findings underscore the importance of clinical neurodevelopmental follow-up and the need for more comprehensive imaging and long-term outcomes research following prenatal opioid exposure. ER -