RT Journal Article
SR Electronic
T1 Functional Brain Imaging Using a Long Intravenous Half-Life Gadolinium-Based Contrast Agent
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 1467
OP 1471
VO 27
IS 7
A1 D.W. Morton
A1 B. Keogh
A1 K. Lim
A1 K.R. Maravilla
YR 2006
UL http://www.ajnr.org/content/27/7/1467.abstract
AB PURPOSE: We describe a technique for functional MR imaging (fMRI) with high spatial and temporal resolution using a long intravascular half-life gadolinium-based contrast agent, MS-325.METHODS: All fMRI measurements used a rat model of sensory cortex activation with forepaw electrical stimulation under α-chloralose anesthesia. Standard blood oxygen level–dependent (BOLD) fMRI measurement was initially performed. MS-325 was then intravenously administered and a MS-325 fMRI measurement was performed by using a 3D gradient-echo sequence.RESULTS: We found that a dose of 0.1 mmol/kg MS-325 produced adequate signal intensity changes in rat sensory cortex to demonstrate activations. Using a boxcar stimulation pattern with a standard correlation analysis, the locations of the most significantly activated voxels (ie, highest Z score) in the MS-325 and BOLD fMRI measurements were not significantly different.CONCLUSIONS: MS-325 fMRI has the advantage of using a T1-weighted sequence, rather than the highly T2*-weighted sequences used in other common fMRI techniques. This could reduce the susceptibility artifacts associated with fMRI.