%0 Journal Article %A D.J. Rigotti %A M. Inglese %A J.S. Babb %A M. Rovaris %A B. Benedetti %A M. Filippi %A R.I. Grossman %A O. Gonen %T Serial Whole-Brain N-Acetylaspartate Concentration in Healthy Young Adults %D 2007 %R 10.3174/ajnr.A0712 %J American Journal of Neuroradiology %P 1650-1651 %V 28 %N 9 %X SUMMARY: Although the concentration of N-acetylaspartate (NAA) is often used as a neuronal integrity marker, its normal temporal variations are not well documented. To assess them over the 1–2 year periods of typical clinical trials, the whole-brain NAA concentration was measured longitudinally, over 4 years, in a cohort of healthy young adults. No significant change (adjusted for both sex and age) was measured either interpersonally or intrapersonally over the entire duration of the study. %U https://www.ajnr.org/content/ajnr/28/9/1650.full.pdf