RT Journal Article
SR Electronic
T1 Effects of Susceptibility Artifacts on Perfusion MRI in Patients with Primary Brain Tumor: A Comparison of Arterial Spin-Labeling versus DSC
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 255
OP 261
DO 10.3174/ajnr.A6384
VO 41
IS 2
A1 H. Maral
A1 E. Ertekin
A1 Ö. Tunçyürek
A1 Y. Özsunar
YR 2020
UL http://www.ajnr.org/content/41/2/255.abstract
AB BACKGROUND AND PURPOSE: Our aim was to investigate the effects of intratumoral hemorrhage, calcification, and postoperative changes on the sensitivity of arterial spin-labeling and DSC perfusion MR imaging in patients with primary brain tumors.MATERIALS AND METHODS: Eighty-six brain tumor lesions were examined with single-phase and multiphase arterial spin-labeling and DSC perfusion MR imaging. The lesions that had no intratumoral bleeding/calcifications and history of surgery were assigned to group 1 (n = 38), and the lesions that had these were assigned to group 2 (n = 48). The relative regional cerebral blood flow was calculated in both perfusion methods, and relative regional cerebral blood volume was calculated in DSC. Imaging results were correlated with histopathology or follow-up.RESULTS: In the quantitative evaluation, the sensitivity and specificity of relative regional cerebral blood flow in multiphase arterial spin-labeling perfusion were 94.4% and 80% in group 1 and 78.3% and 88% in group 2, respectively. The sensitivity and specificity of relative regional cerebral blood flow in DSC perfusion were 88.9% and 75% in group 1 and 78.3% and 84% in group 2, respectively. The sensitivity and specificity of relative regional cerebral blood volume in DSC perfusion were 66.7% and 100% in group 1 and 69.6% and 96% in group 2, respectively. In the qualitative evaluation, the sensitivities for single-phase and multiphase arterial spin-labeling were 48.2% and 79.3%, respectively, with 100% specificity for both.CONCLUSIONS: The sensitivity and specificity of multiphase arterial spin-labeling were similar to those of DSC perfusion irrespective of bleeding and calcification in primary brain tumors. Thus, we suggest that noncontrast multiphase arterial spin-labeling can be used instead of DSC perfusion MR imaging in the diagnosis and follow-up of intracranial tumors.ASLarterial spin-labelingmpASLmultiphase ASLPIperfusion imagingrCBFrelative CBFROCreceiver operating characteristicrrCBFrelative regional CBFrrCBVrelative regional CBVspASLsingle-phase ASL