RT Journal Article
SR Electronic
T1 Utility of a Multiparametric Quantitative MRI Model That Assesses Myelin and Edema for Evaluating Plaques, Periplaque White Matter, and Normal-Appearing White Matter in Patients with Multiple Sclerosis: A Feasibility Study
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
DO 10.3174/ajnr.A4977
A1 A. Hagiwara
A1 M. Hori
A1 K. Yokoyama
A1 M.Y. Takemura
A1 C. Andica
A1 K.K. Kumamaru
A1 M. Nakazawa
A1 N. Takano
A1 H. Kawasaki
A1 S. Sato
A1 N. Hamasaki
A1 A. Kunimatsu
A1 S. Aoki
YR 2016
UL http://www.ajnr.org/content/early/2016/10/27/ajnr.A4977.abstract
AB BACKGROUND AND PURPOSE: T1 and T2 values and proton density can now be quantified on the basis of a single MR acquisition. The myelin and edema in a voxel can also be estimated from these values. The purpose of this study was to evaluate a multiparametric quantitative MR imaging model that assesses myelin and edema for characterizing plaques, periplaque white matter, and normal-appearing white matter in patients with MS.MATERIALS AND METHODS: We examined 3T quantitative MR imaging data from 21 patients with MS. The myelin partial volume, excess parenchymal water partial volume, the inverse of T1 and transverse T2 relaxation times (R1, R2), and proton density were compared among plaques, periplaque white matter, and normal-appearing white matter.RESULTS: All metrics differed significantly across the 3 groups (P < .001). Those in plaques differed most from those in normal-appearing white matter. The percentage changes of the metrics in plaques and periplaque white matter relative to normal-appearing white matter were significantly more different from zero for myelin partial volume (mean, −61.59 ± 20.28% [plaque relative to normal-appearing white matter], and mean, −10.51 ± 11.41% [periplaque white matter relative to normal-appearing white matter]), and excess parenchymal water partial volume (13.82 × 103 ± 49.47 × 103% and 51.33 × 102 ± 155.31 × 102%) than for R1 (−35.23 ± 13.93% and −6.08 ± 8.66%), R2 (−21.06 ± 11.39% and −4.79 ± 6.79%), and proton density (23.37 ± 10.30% and 3.37 ± 4.24%).CONCLUSIONS: Multiparametric quantitative MR imaging captures white matter damage in MS. Myelin partial volume and excess parenchymal water partial volume are more sensitive to the MS disease process than R1, R2, and proton density.AbbreviationsEDSSExpanded Disability Status ScaleNAWMnormal-appearing white matterPDproton densityPWMperiplaque white matterVCLcellular partial volumeVEPWexcess parenchymal water partial volumeVFWfree water partial volumeVMYmyelin partial volume%BPVEPWthe percentage of excess parenchymal water volume in brain parenchyma%BPVMYthe percentage of myelin volume in brain parenchymaQRAPMASTERquantification of relaxation times and proton density by multiecho acquisition of a saturation-recovery using turbo spin-echo readoutR1 and R2inverse of T1 and transverse T2 relaxation times