TY - JOUR T1 - Ratio of T1-Weighted to T2-Weighted Signal Intensity as a Measure of Tissue Integrity: Comparison with Magnetization Transfer Ratio in Patients with Multiple Sclerosis JF - American Journal of Neuroradiology JO - Am. J. Neuroradiol. SP - 461 LP - 463 DO - 10.3174/ajnr.A6481 VL - 41 IS - 3 AU - D. Pareto AU - A. Garcia-Vidal AU - M. Alberich AU - C. Auger AU - X. Montalban AU - M. Tintoré AU - J. Sastre-Garriga AU - À. Rovira Y1 - 2020/03/01 UR - http://www.ajnr.org/content/41/3/461.abstract N2 - SUMMARY: The study aim was to compare the ratio of T1WI to T2WI signal intensity (T1/T2) with magnetization transfer ratio, a marker of myelin integrity, in patients with multiple sclerosis. A moderate correlation (r = 0.50, P = .034) was found between the magnetization transfer ratio and T1/T2 in normal-appearing gray matter, and a strong correlation for normal-appearing white matter (r = 0.63, P = .005) and lesions (r = 0.70, P = .001). Results suggest that besides myelin integrity, other factors may be playing a role in T1/T2 measures.EDSSExpanded Disability Status ScaleMTRmagnetization transfer ratioNAGMnormal-appearing gray matterNAWMnormal-appearing white matterCSFcerebrospinal fluid ER -