RT Journal Article SR Electronic T1 Whole-Brain N-Acetylaspartate Spectroscopy and Diffusion Tensor Imaging in Patients with Newly Diagnosed Gliomas: A Preliminary Study JF American Journal of Neuroradiology JO Am. J. Neuroradiol. FD American Society of Neuroradiology SP 2137 OP 2140 VO 27 IS 10 A1 M. Inglese A1 S. Brown A1 G. Johnson A1 M. Law A1 E. Knopp A1 O. Gonen YR 2006 UL http://www.ajnr.org/content/27/10/2137.abstract AB BACKGROUND AND PURPOSE:Glial cancer cells can be found well beyond the MR imaging T2 signal-intensity hyperintensity. To quantify the extent of the diffuse microstructural tissue damage possibly due to the presence of these satellite tumor cells, we investigated the relationships between global metabolic and microstructural abnormalities in the normal-appearing brain regions of patients with newly diagnosed glioma.MATERIAL AND METHODS:Ten patients (6 men, 4 women) with radiologically suspected untreated supratentorial glial tumors and 9 healthy controls (5 men, 4 women) were studied with T1- and T2-weighted MR imaging, diffusion-weighted echo-planar MR imaging, and whole-brain N-acetylaspartate (WBNAA) proton MR spectroscopy. The relationship between the WBNAA concentration, the mean diffusivity (MD), and fractional anisotropy (FA) values in a large contralateral normal-appearing white matter (NAWM) brain region was investigated with the Spearman rank correlation test.RESULTS:WBNAA values were significantly lower (P < .001) in patients (9.7 ± 1.7 mmol/L) than controls (13.1 ± 1.1 mmol/L). MD values were higher (P = .0001) in patients (0.95 ± 0.07 mm2s−1) than in controls (0.61 ± 0.04 mm2s−1). FA values did not differ between patients (0.42 ± 0.08) and controls (0.43 ± 0.041). A strong inverse correlation between WBNAA and MD (r = −0.88, P = .0008) was found in the patients but not in controls (r = 0.012, P = .975).CONCLUSION:The correlation between the WBNAA and MD in the contralateral NAWM suggests that the microstructural damage possibly related to the presence of infiltrative tumor cells contributes to WBNAA decline in these patients.