@article {McKinney2199, author = {A.M. McKinney and P. Reichert and J. Short and T. Dhurairaj and K. SantaCruz and Z. McKinney and S. Kieffer}, title = {Metachronous, Multicentric Giant Cell Tumor of the Sphenoid Bone with Histologic, CT, MR Imaging, and Positron-Emission Tomography/CT Correlation}, volume = {27}, number = {10}, pages = {2199--2201}, year = {2006}, publisher = {American Journal of Neuroradiology}, abstract = {SUMMARY: Giant cell tumor (GCT) of the sphenoid bone is a relatively rare entity and metachronous multicentric GCT of the sphenoid is even rarer; we are aware of only 3 previous cases in the literature. We describe here a tumor of the sphenoid bone that was identified 15 years after multiple resections of a GCT of the left inferior pubic ramus. Correlation is made between the histopathologic findings, MR imaging of the brain, CT of the head, and fusion positron-emission tomography (PET)/CT scan performed with fluorine-18 fluoro-2-deoxy-D-glucose (18F-FDG). This report is the first to describe the appearance of a GCT of the sphenoid bone on a fusion PET/CT examination. High metabolic activity in the base of the skull adjacent to the middle cranial fossa was demonstrated in a fashion similar to that of the known pelvic lesion. This case also demonstrates that the increased metabolic activity seen in a GCT of the sphenoid bone may be partially obscured by the adjacent physiologic high metabolic activity of the brain.}, issn = {0195-6108}, URL = {https://www.ajnr.org/content/27/10/2199}, eprint = {https://www.ajnr.org/content/27/10/2199.full.pdf}, journal = {American Journal of Neuroradiology} }