PT - JOURNAL ARTICLE AU - A.M. McKinney AU - P. Reichert AU - J. Short AU - T. Dhurairaj AU - K. SantaCruz AU - Z. McKinney AU - S. Kieffer TI - Metachronous, Multicentric Giant Cell Tumor of the Sphenoid Bone with Histologic, CT, MR Imaging, and Positron-Emission Tomography/CT Correlation DP - 2006 Nov 01 TA - American Journal of Neuroradiology PG - 2199--2201 VI - 27 IP - 10 4099 - http://www.ajnr.org/content/27/10/2199.short 4100 - http://www.ajnr.org/content/27/10/2199.full SO - Am. J. Neuroradiol.2006 Nov 01; 27 AB - SUMMARY: Giant cell tumor (GCT) of the sphenoid bone is a relatively rare entity and metachronous multicentric GCT of the sphenoid is even rarer; we are aware of only 3 previous cases in the literature. We describe here a tumor of the sphenoid bone that was identified 15 years after multiple resections of a GCT of the left inferior pubic ramus. Correlation is made between the histopathologic findings, MR imaging of the brain, CT of the head, and fusion positron-emission tomography (PET)/CT scan performed with fluorine-18 fluoro-2-deoxy-D-glucose (18F-FDG). This report is the first to describe the appearance of a GCT of the sphenoid bone on a fusion PET/CT examination. High metabolic activity in the base of the skull adjacent to the middle cranial fossa was demonstrated in a fashion similar to that of the known pelvic lesion. This case also demonstrates that the increased metabolic activity seen in a GCT of the sphenoid bone may be partially obscured by the adjacent physiologic high metabolic activity of the brain.