PT  - JOURNAL ARTICLE
AU  - N.A. Vora
AU  - R. Gupta
AU  - A.J. Thomas
AU  - M.B. Horowitz
AU  - A.H. Tayal
AU  - M.D. Hammer
AU  - K. Uchino
AU  - L.R. Wechsler
AU  - T.G. Jovin
TI  - Factors Predicting Hemorrhagic Complications after Multimodal Reperfusion Therapy for Acute Ischemic Stroke
AID  - 10.3174/ajnr.A0575
DP  - 2007 Aug 01
TA  - American Journal of Neuroradiology
PG  - 1391--1394
VI  - 28
IP  - 7
4099  - http://www.ajnr.org/content/28/7/1391.short
4100  - http://www.ajnr.org/content/28/7/1391.full
SO  - Am. J. Neuroradiol.2007 Aug 01; 28
AB  - BACKGROUND AND PURPOSE: We sought to find predictors for hemorrhagic complications in patients with acute ischemic stroke treated with multimodal endovascular therapy.MATERIALS AND METHODS: We retrospectively reviewed patients with acute ischemic stroke treated with multimodal endovascular therapy from May 1999 to March 2006. We reviewed clinical and angiographic data, admission CT Alberta Stroke Programme Early CT Score (ASPECTS), and the therapeutic endovascular interventions used. Posttreatment CT scans were reviewed for the presence of a parenchymal hematoma or hemorrhagic infarction based on defined criteria. Predictors for these types of hemorrhages were determined by logistic regression analysis.RESULTS: We identified 185 patients with a mean age of 65 ± 13 years and mean National Institutes of Health Stroke Scale score of 17 ± 4. Sixty-nine patients (37%) developed postprocedural hemorrhages: 24 (13%) parenchymal hematomas and 45 (24%) hemorrhagic infarctions. Patients with tandem occlusions (odds ratio [OR] 4.6 [1.4–6.5], P < .016), hyperglycemia (OR 2.8 [1.1–7.7], P < .043), or treated concomitantly with intravenous (IV) tissue plasminogen activator (tPA) and intra-arterial (IA) urokinase (OR 5.1 [1.1–25.0], P < .041) were at a significant risk for a parenchymal hematoma. Hemorrhagic infarction occurred significantly more in patients presenting with an ASPECTS ≤7 (OR 1.9 [1.3–2.7], P < .01).CONCLUSIONS: Hemorrhagic infarctions are related to the extent of infarct based on presentation CT, whereas parenchymal hematomas are associated with the presence of tandem occlusions, hyperglycemia, and treatment with both IV tPA and IA urokinase in patients with acute stroke treated with multimodal endovascular therapy.