PT  - JOURNAL ARTICLE
AU  - R.E. Hogan
AU  - L. Wang
AU  - M.E. Bertrand
AU  - L.J. Willmore
AU  - R.D. Bucholz
AU  - A.S. Nassif
AU  - J.G. Csernansky
TI  - Predictive Value of Hippocampal MR Imaging-Based High-Dimensional Mapping in Mesial Temporal Epilepsy: Preliminary Findings
DP  - 2006 Nov 01
TA  - American Journal of Neuroradiology
PG  - 2149--2154
VI  - 27
IP  - 10
4099  - http://www.ajnr.org/content/27/10/2149.short
4100  - http://www.ajnr.org/content/27/10/2149.full
SO  - Am. J. Neuroradiol.2006 Nov 01; 27
AB  - BACKGROUND AND PURPOSE:We objectively assessed surface structural changes of the hippocampus in mesial temporal sclerosis (MTS) and assessed the ability of large-deformation high-dimensional mapping (HDM-LD) to demonstrate hippocampal surface symmetry and predict group classification of MTS in right and left MTS groups compared with control subjects.METHODS:Using eigenvector field analysis of HDM-LD segmentations of the hippocampus, we compared the symmetry of changes in the right and left MTS groups with a group of 15 matched controls. To assess the ability of HDM-LD to predict group classification, eigenvectors were selected by a logistic regression procedure when comparing the MTS group with control subjects.RESULTS:Multivariate analysis of variance on the coefficients from the first 9 eigenvectors accounted for 75% of the total variance between groups. The first 3 eigenvectors showed the largest differences between the control group and each of the MTS groups, but with eigenvector 2 showing the greatest difference in the MTS groups. Reconstruction of the hippocampal deformation vector fields due solely to eigenvector 2 shows symmetrical patterns in the right and left MTS groups. A “leave-one-out” (jackknife) procedure correctly predicted group classification in 14 of 15 (93.3%) left MTS subjects and all 15 right MTS subjects.CONCLUSION:Analysis of principal dimensions of hippocampal shape change suggests that MTS, after accounting for normal right-left asymmetries, affects the right and left hippocampal surface structure very symmetrically. Preliminary analysis using HDM-LD shows it can predict group classification of MTS and control hippocampi in this well-defined population of patients with MTS and mesial temporal lobe epilepsy (MTLE).