TY - JOUR T1 - Excitotoxicity in Acute Encephalopathy with Biphasic Seizures and Late Reduced Diffusion JF - American Journal of Neuroradiology JO - Am. J. Neuroradiol. SP - 132 LP - 135 DO - 10.3174/ajnr.A1247 VL - 30 IS - 1 AU - J. Takanashi AU - H. Tada AU - H. Terada AU - A.J. Barkovich Y1 - 2009/01/01 UR - http://www.ajnr.org/content/30/1/132.abstract N2 - SUMMARY: Acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) is a recently described clinicoradiologic syndrome. MR spectroscopy in 3 patients with AESD revealed decreased N-acetylaspartate (NAA) and elevated glutamine/glutamate complex (Glx) during the week of presentation. Afterward, Glx normalized, whereas NAA remained low in 2 patients with neurologic sequelae but nearly normalized in the third patient without neurologic sequelae. These findings support the hypothesis that excitotoxic neuronal damage plays an important role in the pathogenesis of AESD and suggest that MR spectroscopy might be predictive of outcome. ER -