RT Journal Article SR Electronic T1 Excitotoxicity in Acute Encephalopathy with Biphasic Seizures and Late Reduced Diffusion JF American Journal of Neuroradiology JO Am. J. Neuroradiol. FD American Society of Neuroradiology SP 132 OP 135 DO 10.3174/ajnr.A1247 VO 30 IS 1 A1 J. Takanashi A1 H. Tada A1 H. Terada A1 A.J. Barkovich YR 2009 UL http://www.ajnr.org/content/30/1/132.abstract AB SUMMARY: Acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) is a recently described clinicoradiologic syndrome. MR spectroscopy in 3 patients with AESD revealed decreased N-acetylaspartate (NAA) and elevated glutamine/glutamate complex (Glx) during the week of presentation. Afterward, Glx normalized, whereas NAA remained low in 2 patients with neurologic sequelae but nearly normalized in the third patient without neurologic sequelae. These findings support the hypothesis that excitotoxic neuronal damage plays an important role in the pathogenesis of AESD and suggest that MR spectroscopy might be predictive of outcome.