PT  - JOURNAL ARTICLE
AU  - Brewer, J.B.
AU  - Magda, S.
AU  - Airriess, C.
AU  - Smith, M.E.
TI  - Fully-Automated Quantification of Regional Brain Volumes for Improved Detection of Focal Atrophy in Alzheimer Disease
AID  - 10.3174/ajnr.A1402
DP  - 2009 Mar 01
TA  - American Journal of Neuroradiology
PG  - 578--580
VI  - 30
IP  - 3
4099  - http://www.ajnr.org/content/30/3/578.short
4100  - http://www.ajnr.org/content/30/3/578.full
SO  - Am. J. Neuroradiol.2009 Mar 01; 30
AB  - SUMMARY: Volumetric analysis of structural MR images of the brain may provide quantitative evidence of neurodegeneration and help identify patients at risk for rapid clinical deterioration. This note describes tests of a fully automated MR imaging postprocessing system for volumetric analysis of structures (such as the hippocampus) known to be affected in early Alzheimer disease (AD). The system yielded results that correlated highly with independent computer-aided manual segmentation and were sensitive to the anatomic atrophy characteristic of mild AD.