RT Journal Article
SR Electronic
T1 Radiologically Isolated Syndrome: A Review for Neuroradiologists
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 1542
OP 1549
DO 10.3174/ajnr.A6649
VO 41
IS 9
A1 M. Hosseiny
A1 S.D. Newsome
A1 D.M. Yousem
YR 2020
UL http://www.ajnr.org/content/41/9/1542.abstract
AB SUMMARY: Radiologically isolated syndrome refers to an entity in which white matter lesions fulfilling the criteria for multiple sclerosis occur in individuals without a history of a clinical demyelinating attack or alternative etiology. Since its introduction in 2009, the diagnostic criteria of radiologically isolated syndrome and its clinical relevance have been widely debated by neurologists and radiologists. The aim of the present study was to review the following: 1) historical evolution of radiologically isolated syndrome criteria, 2) clinical and imaging findings in adults and children with radiologically isolated syndrome, 3) imaging features of patients with radiologically isolated syndrome at high risk for conversion to MS, and 4) challenges and controversies for work-up, management, and therapeutic interventions of patients with radiologically isolated syndrome.CISclinically isolated syndromeDISdissemination in spaceDITdissemination in timeMAGNIMSMagnetic Resonance Imaging in MSRISradiologically isolated syndromeRRMSrelapsing-remitting multiple sclerosisCADASILcerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathyADEMacute disseminated encephalomyelitis