PT  - JOURNAL ARTICLE
AU  - M. Lang
AU  - K. Buch
AU  - M.D. Li
AU  - W.A. Mehan, Jr
AU  - A.L. Lang
AU  - T.M. Leslie-Mazwi
AU  - S.P. Rincon
TI  - Leukoencephalopathy Associated with Severe COVID-19 Infection: Sequela of Hypoxemia?
AID  - 10.3174/ajnr.A6671
DP  - 2020 Sep 01
TA  - American Journal of Neuroradiology
PG  - 1641--1645
VI  - 41
IP  - 9
4099  - http://www.ajnr.org/content/41/9/1641.short
4100  - http://www.ajnr.org/content/41/9/1641.full
SO  - Am. J. Neuroradiol.2020 Sep 01; 41
AB  - SUMMARY: There is increasing evidence to suggest that complications of coronavirus disease 2019 (COVID-19) infection are not only limited to the pulmonary system but can also involve the central nervous system. Here, we report 6 critically ill patients with COVID-19 infection and neuroimaging findings of leukoencephalopathy. While these findings are nonspecific, we postulate that they may be a delayed response to the profound hypoxemia the patients experienced due to the infection. No abnormal enhancement, hemorrhage, or perfusion abnormalities were noted on MR imaging. In addition, Severe Acute Respiratory Syndrome coronavirus 2 was not detected in the CSF collected from the 2 patients who underwent lumbar puncture. Recognition of COVID-19-related leukoencephalopathy is important for appropriate clinical management, disposition, and prognosis.COVID-19coronavirus disease 2019PaO2partial pressure of oxygenSARS-CoV-2Severe Acute Respiratory Syndrome coronavirus 2MRmagnetic resonanceCTcomputed tomographyCSFcerebrospinal fluid