RT Journal Article
SR Electronic
T1 Reversible Encephalopathy after Cardiac Transplantation: Histologic Evidence of Endothelial Activation, T-Cell Specific Trafficking, and Vascular Endothelial Growth Factor Expression
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 588
OP 590
DO 10.3174/ajnr.A1311
VO 30
IS 3
A1 C. Horbinski
A1 W.S. Bartynski
A1 E. Carson-Walter
A1 R.L. Hamilton
A1 H.P. Tan
A1 S. Cheng
YR 2009
UL http://www.ajnr.org/content/30/3/588.abstract
AB SUMMARY: Reversible encephalopathy after transplantation is well recognized. The condition is commonly thought to be related to immune suppression, and a characteristic brain imaging pattern is typically recognized with vasogenic edema in the parietal and occipital regions, typically termed posterior reversible encephalopathy syndrome (PRES). We report the case of a patient with reversible encephalopathy after cardiac transplantation with brain biopsy evidence of endothelial activation, selective intravascular/perivascular T-cell trafficking, and VEGF expression in astrocytes, neurons, and the endothelium.