RT Journal Article
SR Electronic
T1 The Perplexity Surrounding Chiari Malformations – Are We Any Wiser Now?
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
DO 10.3174/ajnr.A6743
A1 S.B. Hiremath
A1 A. Fitsiori
A1 J. Boto
A1 C. Torres
A1 N. Zakhari
A1 J.-L. Dietemann
A1 T.R. Meling
A1 M.I. Vargas
YR 2020
UL http://www.ajnr.org/content/early/2020/09/17/ajnr.A6743.abstract
AB SUMMARY: Chiari malformations are a diverse group of abnormalities of the brain, craniovertebral junction, and the spine. Chiari 0, I, and 1.5 malformations, likely a spectrum of the same malformation with increasing severity, are due to the inadequacy of the para-axial mesoderm, which leads to insufficient development of occipital somites. Chiari II malformation is possibly due to nonclosure of the caudal end of the neuropore, with similar pathogenesis in the rostral end, which causes a Chiari III malformation. There have been significant developments in the understanding of this complex entity owing to insights into the pathogenesis and advancements in imaging modalities and neurosurgical techniques. This article aims to review the different types and pathophysiology of the Chiari malformations, along with a description of the various associated abnormalities. We also highlight the role of ante- and postnatal imaging, with a focus on the newer techniques in the presurgical evaluation, with a brief mention of the surgical procedures and the associated postsurgical complications.CMChiari malformation