RT Journal Article
SR Electronic
T1 Clinical and Radiologic Findings of Acute Necrotizing Encephalopathy in Young Adults
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
DO 10.3174/ajnr.A6803
A1 H.A. Vanjare
A1 B.T. Selvi
A1 R. Karuppusami
A1 A. Manesh
A1 K. Gunasekaran
A1 A.T. Prabhakar
A1 P. Mannam
A1 A. Jasper
YR 2020
UL http://www.ajnr.org/content/early/2020/10/29/ajnr.A6803.abstract
AB SUMMARY: Acute necrotizing encephalopathy after an acute febrile illness, although initially described exclusively in the pediatric age group, has been recently shown to have an adult onset as well. In this study, we describe 10 patients (16 years of age or older) with acute necrotizing encephalopathy. In our study, bilateral thalamic involvement with the trilaminar pattern of diffusion restriction on MR imaging was the predominant finding seen in all of the patients reviewed. Ancillary findings of cerebral white matter, brain stem, and cerebellum involvement with sparing of the basal ganglia were also noted. A poorer outcome was observed in patients with a higher degree of thalamic involvement. The cause of an underlying infection was identified in 4 patients (dengue in 3 and influenza in 1). Overall, a sizeable portion of young adults with acute necrotizing encephalopathy have shown a poorer outcome, with dengue being an important underlying trigger in an endemic region.ANEacute necrotizing encephalopathy