RT Journal Article
SR Electronic
T1 Brain MR Spectroscopic Findings in 3 Consecutive Patients with COVID-19: Preliminary Observations
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
DO 10.3174/ajnr.A6877
A1 O. Rapalino
A1 A. Weerasekera
A1 S.J. Moum
A1 K. Eikermann-Haerter
A1 B.L. Edlow
A1 D. Fischer
A1 A. Torrado-Carvajal
A1 M.L. Loggia
A1 S.S. Mukerji
A1 P.W. Schaefer
A1 R.G. Gonzalez
A1 M.H. Lev
A1 E.-M. Ratai
YR 2020
UL http://www.ajnr.org/content/early/2020/10/29/ajnr.A6877.abstract
AB SUMMARY: Brain multivoxel MR spectroscopic imaging was performed in 3 consecutive patients with coronavirus disease 2019 (COVID-19). These included 1 patient with COVID-19-associated necrotizing leukoencephalopathy, another patient who had a recent pulseless electrical activity cardiac arrest with subtle white matter changes, and a patient without frank encephalopathy or a recent severe hypoxic episode. The MR spectroscopic imaging findings were compared with those of 2 patients with white matter pathology not related to Severe Acute Respiratory Syndrome coronavirus 2 infection and a healthy control subject. The NAA reduction, choline elevation, and glutamate/glutamine elevation found in the patient with COVID-19-associated necrotizing leukoencephalopathy and, to a lesser degree, the patient with COVID-19 postcardiac arrest, follow a similar pattern as seen with the patient with delayed posthypoxic leukoencephalopathy. Lactate elevation was most pronounced in the patient with COVID-19 necrotizing leukoencephalopathy.COVID-19coronavirus disease 2019DPLdelayed posthypoxic leukoencephalopathyLaclactatePEApulseless electrical activitySAEsepsis-associated encephalopathySARS-CoV-2Severe Acute Respiratory Syndrome coronavirus 2