PT  - JOURNAL ARTICLE
AU  - A.F. Geraldo
AU  - A. Parodi
AU  - M. Bertamino
AU  - F. Buffelli
AU  - S. Uccella
AU  - D. Tortora
AU  - P. Moretti
AU  - L. Ramenghi
AU  - E. Fulcheri
AU  - A. Rossi
AU  - M. Severino
TI  - Perinatal Arterial Ischemic Stroke in Fetal Vascular Malperfusion: A Case Series and Literature Review
AID  - 10.3174/ajnr.A6857
DP  - 2020 Oct 29
TA  - American Journal of Neuroradiology
4099  - http://www.ajnr.org/content/early/2020/10/29/ajnr.A6857.short
4100  - http://www.ajnr.org/content/early/2020/10/29/ajnr.A6857.full
AB  - SUMMARY: Fetal vascular malperfusion includes a continuum of placental histologic abnormalities increasingly associated with perinatal brain injury, namely arterial ischemic stroke. Here, we describe the clinical-neuroimaging features of 5 neonates with arterial ischemic stroke and histologically proved fetal vascular malperfusion. All infarcts involved the anterior territories and were multiple in 2 patients. In 2 neonates, there were additional signs of marked dural sinus congestion, thrombosis, or both. A mixed pattern of chronic hypoxic-ischemic encephalopathy and acute infarcts was noted in 1 patient at birth. Systemic cardiac or thrombotic complications were present in 2 patients. These peculiar clinical-radiologic patterns may suggest fetal vascular malperfusion and should raise the suspicion of this rare, underdiagnosed condition carrying important implications in patient management, medicolegal actions, and future pregnancy counseling.FVMfetal vascular malperfusionPAISperinatal arterial ischemic stroke