TY - JOUR T1 - Anomalous J-Modulation Effects on Amino Acids in Clinical 3T MR Spectroscopy JF - American Journal of Neuroradiology JO - Am. J. Neuroradiol. SP - 1644 LP - 1648 DO - 10.3174/ajnr.A1131 VL - 29 IS - 9 AU - H.-S. Liu AU - H.-W. Chung AU - C.-J. Juan AU - S.-Y. Tsai AU - C.-Y. Wang AU - C.-C. Chan AU - G.-S. Huang AU - M.-C. Chou AU - C.-S. Lee AU - C.-W. Ko AU - N.-Y. Cho AU - C.-Y. Chen Y1 - 2008/10/01 UR - http://www.ajnr.org/content/29/9/1644.abstract N2 - SUMMARY: The signal-intensity loss from anomalous J-modulation effects due to chemical-shift displacement was investigated on amino acid groups (alanine, valine, leucine, and isoleucine) at 3T by using point-resolved 1H spectroscopy in patients with brain abscess and phantom experiments. With a larger chemical shift between methyl and methine resonances, alanine shows a greater effect of signal-intensity cancellation compared with other amino acids around 0.9 ppm, resulting in noninverted doublets at a TE of 144 ms. ER -