PT  - JOURNAL ARTICLE
AU  - K.J. Carpenter
AU  - R.D. Murtagh
AU  - H. Lilienfeld
AU  - J. Weber
AU  - F.R. Murtagh
TI  - Ipilimumab-Induced Hypophysitis: MR Imaging Findings
AID  - 10.3174/ajnr.A1623
DP  - 2009 Oct 01
TA  - American Journal of Neuroradiology
PG  - 1751--1753
VI  - 30
IP  - 9
4099  - http://www.ajnr.org/content/30/9/1751.short
4100  - http://www.ajnr.org/content/30/9/1751.full
SO  - Am. J. Neuroradiol.2009 Oct 01; 30
AB  - SUMMARY: Ipilimumab is a promising new immunotherapeutic antineoplastic agent with clinical activity in the treatment of metastatic melanoma and renal cell carcinoma. With advances in immunotherapy, however, a host of new side effects related to the mechanism of action of these drugs has appeared. At our institution, 3 patients presented with hypophysitis, which was attributed to an autoimmune process based on the documented relationship of the drug to other autoimmune phenomena and significant and rapid improvement with discontinuation of the drug and addition of steroids. We present the imaging findings in 3 patients with presumed ipilimumab-induced hypophysitis.