TY - JOUR T1 - Multiple familial cavernous malformations evaluated over three generations with MR. JF - American Journal of Neuroradiology JO - Am. J. Neuroradiol. SP - 1353 LP - 1355 VL - 16 IS - 6 AU - M Horowitz AU - D Kondziolka Y1 - 1995/06/01 UR - http://www.ajnr.org/content/16/6/1353.abstract N2 - MR imaging was used to determine the presence or absence of cavernous malformations in three generations of family members. The presenting child (proband) had sustained a symptomatic hemorrhage. Multiple malformations were identified in his father, in an older sibling, and in an asymptomatic grandfather. The father's brother had died from cavernous malformation-related intracerebral hemorrhage. Increasing numbers of malformations were found with increasing patient age, suggesting that MR-apparent lesions may grow in number as a result of repetitive small hemorrhages over time. ER -