%0 Journal Article %A O. Rapalino %A A. Weerasekera %A S.J. Moum %A K. Eikermann-Haerter %A B.L. Edlow %A D. Fischer %A A. Torrado-Carvajal %A M.L. Loggia %A S.S. Mukerji %A P.W. Schaefer %A R.G. Gonzalez %A M.H. Lev %A E.-M. Ratai %T Brain MR Spectroscopic Findings in 3 Consecutive Patients with COVID-19: Preliminary Observations %D 2021 %R 10.3174/ajnr.A6877 %J American Journal of Neuroradiology %P 37-41 %V 42 %N 1 %X SUMMARY: Brain multivoxel MR spectroscopic imaging was performed in 3 consecutive patients with coronavirus disease 2019 (COVID-19). These included 1 patient with COVID-19-associated necrotizing leukoencephalopathy, another patient who had a recent pulseless electrical activity cardiac arrest with subtle white matter changes, and a patient without frank encephalopathy or a recent severe hypoxic episode. The MR spectroscopic imaging findings were compared with those of 2 patients with white matter pathology not related to Severe Acute Respiratory Syndrome coronavirus 2 infection and a healthy control subject. The NAA reduction, choline elevation, and glutamate/glutamine elevation found in the patient with COVID-19-associated necrotizing leukoencephalopathy and, to a lesser degree, the patient with COVID-19 postcardiac arrest, follow a similar pattern as seen with the patient with delayed posthypoxic leukoencephalopathy. Lactate elevation was most pronounced in the patient with COVID-19 necrotizing leukoencephalopathy.COVID-19coronavirus disease 2019DPLdelayed posthypoxic leukoencephalopathyLaclactatePEApulseless electrical activitySAEsepsis-associated encephalopathySARS-CoV-2Severe Acute Respiratory Syndrome coronavirus 2 %U https://www.ajnr.org/content/ajnr/42/1/37.full.pdf