RT Journal Article
SR Electronic
T1 Automated Cerebral Hemorrhage Detection Using RAPID
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 273
OP 278
DO 10.3174/ajnr.A6926
VO 42
IS 2
A1 J.J. Heit
A1 H. Coelho
A1 F.O. Lima
A1 M. Granja
A1 A. Aghaebrahim
A1 R. Hanel
A1 K. Kwok
A1 H. Haerian
A1 C.W. Cereda
A1 C. Venkatasubramanian
A1 S. Dehkharghani
A1 L.A. Carbonera
A1 J. Wiener
A1 K. Copeland
A1 F. Mont’Alverne
YR 2021
UL http://www.ajnr.org/content/42/2/273.abstract
AB BACKGROUND AND PURPOSE: Intracranial hemorrhage (ICH) is an important event that is diagnosed on head NCCT. Increased NCCT utilization in busy hospitals may limit timely identification of ICH. RAPID ICH is an automated hybrid 2D–3D convolutional neural network application designed to detect ICH that may allow for expedited ICH diagnosis. We determined the accuracy of RAPID ICH for ICH detection and ICH volumetric quantification on NCCT.MATERIALS AND METHODS: NCCT scans were evaluated for ICH by RAPID ICH. Consensus detection of ICH by 3 neuroradiology experts was used as the criterion standard for RAPID ICH comparison. ICH volume was also automatically determined by RAPID ICH in patients with intraparenchymal or intraventricular hemorrhage and compared with manually segmented ICH volumes by a single neuroradiology expert. ICH detection accuracy, sensitivity, specificity, positive predictive value, negative predictive value, and positive and negative likelihood ratios by RAPID ICH were determined.RESULTS: We included 308 studies. RAPID ICH correctly identified 151/158 ICH cases and 143/150 ICH-negative cases, which resulted in high sensitivity (0.956, CI: 0.911–0.978), specificity (0.953, CI: 0.907–0.977), positive predictive value (0.956, CI: 0.911-0.978), and negative predictive value (0.953, CI: 0.907–0.977) for ICH detection. The positive likelihood ratio (20.479, CI 9.928–42.245) and negative likelihood ratio (0.046, CI 0.023–0.096) for ICH detection were similarly favorable. RAPID ICH volumetric quantification for intraparenchymal and intraventricular hemorrhages strongly correlated with expert manual segmentation (correlation coefficient r = 0.983); the median absolute error was 3 mL.CONCLUSIONS: RAPID ICH is highly accurate in the detection of ICH and in the volumetric quantification of intraparenchymal and intraventricular hemorrhages.CNNconvolutional neural networkICHintracranial hemorrhageLRlikelihood ratioNPVnegative predictive valuePPVpositive predictive value