TY - JOUR T1 - Clinical positron emission tomography for brain tumors: comparison of fludeoxyglucose F 18 and L-methyl-11C-methionine. JF - American Journal of Neuroradiology JO - Am. J. Neuroradiol. SP - 345 LP - 353 VL - 17 IS - 2 AU - T Ogawa AU - A Inugami AU - J Hatazawa AU - I Kanno AU - M Murakami AU - N Yasui AU - K Mineura AU - K Uemura Y1 - 1996/02/01 UR - http://www.ajnr.org/content/17/2/345.abstract N2 - PURPOSE To evaluate the differences between fludeoxyglucose F 18 (FDG) and L-methyl-11C-methionine (11C-methionine) as tracers for positron emission tomography (PET) in the evaluation of brain tumors.METHODS We analyzed 10 patients with histologically verified cerebral glioma or meningioma and 1 patient with a neuroradiologic diagnosis of low-grade glioma by using FDG, 11C-methionine, and PET. We qualitatively and quantitatively evaluated the extent and degree of accumulation of FDG and 11C-methionine in the tumor tissue.RESULTS Although PET with FDG depicted malignant tumors as a hot spot in all cases, it was not able to delineate the extent of the tumor. Conversely, PET with 11C-methionine outlined the tumors as areas of increased accumulation of 11C-methionine, regardless of the degree of malignancy.CONCLUSION PET with FDG and with 11C-methionine can play complementary roles in the evaluation of brain tumors. ER -