RT Journal Article
SR Electronic
T1 A Systematic Review of Procedural Complications from Transforaminal Lumbar Puncture for Intrathecal Nusinersen Administration in Patients with Spinal Muscular Atrophy
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
DO 10.3174/ajnr.A7009
A1 A. Grayev
A1 M. Schoepp
A1 A. Kuner
YR 2021
UL http://www.ajnr.org/content/early/2021/02/25/ajnr.A7009.abstract
AB BACKGROUND: Spinal muscular atrophy is a progressive neurodegenerative disorder that can be treated with intrathecal antisense oligonucleotide therapy (nusinersen). However, administration is often complicated by posterior spinal fusion and neuromuscular scoliosis, necessitating a transforaminal approach.PURPOSE: To assess the safety profile of the transforaminal approach for intrathecal access.DATA SOURCES: Searches of the PubMed, Web of Science, and SCOPUS databases.STUDY SELECTION: Thirteen articles were selected based on inclusion of transforaminal access and appropriate clinical information about the procedure.DATA ANALYSIS: Complications were taken from the included articles and aggregated based on Cardiovascular and Interventional Radiological Society of Europe scale adverse event grading.DATA SYNTHESIS: Total number of complications and grade of complications were analyzed, by year and in total.LIMITATIONS: Selection bias in publication, small patient population size, and variability of the procedure limits the available data.CONCLUSIONS: Transforaminal approach is a safe alternative for intrathecal access in patients with spinal muscular atrophy and may be applicable to a larger patient population.CBCTconebeam CTCIRSECardiovascular and Interventional Radiological Society of EuropeSMAspinal muscular atrophy