TY - JOUR T1 - Whipple disease confined to the central nervous system in childhood. JF - American Journal of Neuroradiology JO - Am. J. Neuroradiol. SP - 1589 LP - 1591 VL - 17 IS - 8 AU - T P Duprez AU - C B Grandin AU - C Bonnier AU - C W Thauvoy AU - J F Gadisseux AU - J L Dutrieux AU - P Evrard Y1 - 1996/09/01 UR - http://www.ajnr.org/content/17/8/1589.abstract N2 - In a case of pediatric Whipple disease confined to the central nervous system, white matter lesions initially appeared as areas of very low signal intensity on T1-weighted MR images and as areas of hyperintensity on proton density-weighted and T2-weighted images, and showed slight peripheral enhancement on delayed contrast-enhanced T1-weighted images. On MR studies obtained 3 and 6 months after antibiotic therapy, the lesions had decreased in size and no longer enhanced. They became progressively less hypointense on T1-weighted images and less hyperintense on T2-weighted images. ER -