RT Journal Article SR Electronic T1 Whipple disease confined to the central nervous system in childhood. JF American Journal of Neuroradiology JO Am. J. Neuroradiol. FD American Society of Neuroradiology SP 1589 OP 1591 VO 17 IS 8 A1 T P Duprez A1 C B Grandin A1 C Bonnier A1 C W Thauvoy A1 J F Gadisseux A1 J L Dutrieux A1 P Evrard YR 1996 UL http://www.ajnr.org/content/17/8/1589.abstract AB In a case of pediatric Whipple disease confined to the central nervous system, white matter lesions initially appeared as areas of very low signal intensity on T1-weighted MR images and as areas of hyperintensity on proton density-weighted and T2-weighted images, and showed slight peripheral enhancement on delayed contrast-enhanced T1-weighted images. On MR studies obtained 3 and 6 months after antibiotic therapy, the lesions had decreased in size and no longer enhanced. They became progressively less hypointense on T1-weighted images and less hyperintense on T2-weighted images.