@article {Cawley1761, author = {C M Cawley and R C Dawson and G Shengelaia and G Bonner and D L Barrow and A R Colohan}, title = {Arterial saccular aneurysm model in the rabbit.}, volume = {17}, number = {9}, pages = {1761--1766}, year = {1996}, publisher = {American Journal of Neuroradiology}, abstract = {Saccular aneurysms arising from the common carotid artery in the neck at the origin of the internal carotid artery were created in male rabbits using the stump of a ligated external carotid artery. These stumps were intraluminally perfused with varying concentrations of porcine pancreatic elastase for 45 minutes via a microcatheter introduced into the femoral artery. The aneurysms were allowed to mature for 2 to 12 weeks. Gross examination and histologic studies confirmed the presence of an aneurysm in all 15 experiments. Ninety-two percent (12 of 13) of the aneurysms studied by postoperative angiography were shown to be angiographically patent: 40\% of all aneurysms were noted to be patent at harvest; and the remainder showed evidence of intraluminal thrombus. On histologic examination, all aneurysms showed complete loss of elastic lamina without evidence of fibrosis or scarring.}, issn = {0195-6108}, URL = {https://www.ajnr.org/content/17/9/1761}, eprint = {https://www.ajnr.org/content/17/9/1761.full.pdf}, journal = {American Journal of Neuroradiology} }