TY - JOUR T1 - MR enhancement of brain lesions: increased contrast dose compared with magnetization transfer. JF - American Journal of Neuroradiology JO - Am. J. Neuroradiol. SP - 1853 LP - 1859 VL - 17 IS - 10 AU - M Knauth AU - M Forsting AU - M Hartmann AU - S Heiland AU - T Balzer AU - K Sartor Y1 - 1996/11/01 UR - http://www.ajnr.org/content/17/10/1853.abstract N2 - PURPOSE To compare image contrast and lesion conspicuity of enhancing intracranial lesions obtained with T1-weighted and magnetization transfer T1-weighted spin-echo sequences after administration of standard (0.1 mmol/kg body weight) and triple doses of gadobutrol.METHODS Twenty-four patients with a total of 34 enhancing intracranial lesions were studied with T1-weighted and magnetization transfer T1-weighted spin-echo MR imaging. An incremental dose technique was used with intravenous injections of 0.1 and 0.2 mmol/kg body weight gadobutrol. Lesion-to-white matter contrast and white matter-to-edema contrast were calculated.RESULTS The lesion-to-white matter contrast of the magnetization transfer T1-weighted studies was significantly higher than that of the T1-weighted studies when identical doses of gadobutrol were compared. The lesion-to-white matter contrast was not significantly different on the triple-dose T1-weighted study and the standard-dose magnetization transfer T1-weighted study. Two lesions were visible only on the standard-dose magnetization transfer T1-weighted and the triple-dose studies.CONCLUSION Standard-dose magnetization transfer T1-weighted and triple-dose T1-weighted spin-echo MR studies are equally well suited to increase the lesion-to-white matter contrast in patients with enhancing intracranial lesions. Triple-dose magnetization transfer T1-weighted studies further increase lesion-to-white matter contrast but do not show additional lesions. ER -