@article {Phillips1299, author = {N.L. Phillips and A.S. Shatil and C. Go and A. Robertson and E. Widjaja}, title = {Resting-State Functional MRI for Determining Language Lateralization in Children with Drug-Resistant Epilepsy}, volume = {42}, number = {7}, pages = {1299--1304}, year = {2021}, doi = {10.3174/ajnr.A7110}, publisher = {American Journal of Neuroradiology}, abstract = {BACKGROUND AND PURPOSE: Task-based fMRI is a noninvasive method of determining language dominance; however, not all children can complete language tasks due to age, cognitive/intellectual, or language barriers. Task-free approaches such as resting-state fMRI offer an alternative method. This study evaluated resting-state fMRI for predicting language laterality in children with drug-resistant epilepsy.MATERIALS AND METHODS: A retrospective review of 43 children with drug-resistant epilepsy who had undergone resting-state fMRI and task-based fMRI during presurgical evaluation was conducted. Independent component analysis of resting-state fMRI was used to identify language networks by comparing the independent components with a language network template. Concordance rates in language laterality between resting-state fMRI and each of the 4 task-based fMRI language paradigms (auditory description decision, auditory category, verbal fluency, and silent word generation tasks) were calculated.RESULTS: Concordance ranged from 0.64 (95\% CI, 0.48{\textendash}0.65) to 0.73 (95\% CI, 0.58{\textendash}0.87), depending on the language paradigm, with the highest concordance found for the auditory description decision task. Most (78\%{\textendash}83\%) patients identified as left-lateralized on task-based fMRI were correctly classified as left-lateralized on resting-state fMRI. No patients classified as right-lateralized or bilateral on task-based fMRI were correctly classified by resting-state fMRI.CONCLUSIONS: While resting-state fMRI correctly classified most patients who had typical (left) language dominance, its ability to correctly classify patients with atypical (right or bilateral) language dominance was poor. Further study is required before resting-state fMRI can be used clinically for language mapping in the context of epilepsy surgery evaluation in children with drug-resistant epilepsy.ACTauditory category taskADDTauditory description decision taskDREdrug-resistant epilepsyICindependent componentICAindependent component analysisLIlaterality indexrs-fMRIresting-state fMRISWGsilent word generationtb-fMRItask-based fMRIVFverbal fluency.}, issn = {0195-6108}, URL = {https://www.ajnr.org/content/42/7/1299}, eprint = {https://www.ajnr.org/content/42/7/1299.full.pdf}, journal = {American Journal of Neuroradiology} }