TY - JOUR T1 - Cerebral Venous Thrombosis in COVID-19: A New York Metropolitan Cohort Study JF - American Journal of Neuroradiology JO - Am. J. Neuroradiol. SP - 1196 LP - 1200 DO - 10.3174/ajnr.A7134 VL - 42 IS - 7 AU - F. Al-Mufti AU - K. Amuluru AU - R. Sahni AU - K. Bekelis AU - R. Karimi AU - J. Ogulnick AU - J. Cooper AU - P. Overby AU - R. Nuoman AU - A. Tiwari AU - K. Berekashvili AU - N. Dangayach AU - J. Liang AU - G. Gupta AU - P. Khandelwal AU - J.F. Dominguez AU - T. Sursal AU - H. Kamal AU - K. Dakay AU - B. Taylor AU - E. Gulko AU - M. El-Ghanem AU - S.A. Mayer AU - C. Gandhi Y1 - 2021/07/01 UR - http://www.ajnr.org/content/42/7/1196.abstract N2 - BACKGROUND AND PURPOSE: Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) infection is associated with hypercoagulability. We sought to evaluate the demographic and clinical characteristics of cerebral venous thrombosis among patients hospitalized for coronavirus disease 2019 (COVID-19) at 6 tertiary care centers in the New York City metropolitan area.MATERIALS AND METHODS: We conducted a retrospective multicenter cohort study of 13,500 consecutive patients with COVID-19 who were hospitalized between March 1 and May 30, 2020.RESULTS: Of 13,500 patients with COVID-19, twelve had imaging-proved cerebral venous thrombosis with an incidence of 8.8 per 10,000 during 3 months, which is considerably higher than the reported incidence of cerebral venous thrombosis in the general population of 5 per million annually. There was a male preponderance (8 men, 4 women) and an average age of 49 years (95% CI, 36–62 years; range, 17–95 years). Only 1 patient (8%) had a history of thromboembolic disease. Neurologic symptoms secondary to cerebral venous thrombosis occurred within 24 hours of the onset of the respiratory and constitutional symptoms in 58% of cases, and 75% had venous infarction, hemorrhage, or both on brain imaging. Management consisted of anticoagulation, endovascular thrombectomy, and surgical hematoma evacuation. The mortality rate was 25%.CONCLUSIONS: Early evidence suggests a higher-than-expected frequency of cerebral venous thrombosis among patients hospitalized for COVID-19. Cerebral venous thrombosis should be included in the differential diagnosis of neurologic syndromes associated with SARS-CoV-2 infection.COVID-19coronavirus disease 2019CVSTcerebral venous sinus thrombosisCVTcerebral venous thrombosisSARS-CoV-2Severe Acute Respiratory Syndrome coronavirus 2 ER -