RT Journal Article
SR Electronic
T1 Roadmap Consensus on Carotid Artery Plaque Imaging and Impact on Therapy Strategies and Guidelines: An International, Multispecialty, Expert Review and Position Statement
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
DO 10.3174/ajnr.A7223
A1 L. Saba
A1 W. Brinjikji
A1 J.D. Spence
A1 M. Wintermark
A1 M. Castillo
A1 G.J.D. Borst
A1 Q. Yang
A1 C. Yuan
A1 A. Buckler
A1 M. Edjlali
A1 T. Saam
A1 D. Saloner
A1 B.K. Lal
A1 D. Capodanno
A1 J. Sun
A1 N. Balu
A1 R. Naylor
A1 A.v.d. Lugt
A1 B.A. Wasserman
A1 M.E. Kooi
A1 J. Wardlaw
A1 J. Gillard
A1 G. Lanzino
A1 U. Hedin
A1 D. Mikulis
A1 A. Gupta
A1 J.K. DeMarco
A1 C. Hess
A1 J.V. Goethem
A1 T. Hatsukami
A1 P. Rothwell
A1 M.M. Brown
A1 A.R. Moody
YR 2021
UL http://www.ajnr.org/content/early/2021/07/29/ajnr.A7223.abstract
AB SUMMARY: Current guidelines for primary and secondary prevention of stroke in patients with carotid atherosclerosis are based on the quantification of the degree of stenosis and symptom status. Recent publications have demonstrated that plaque morphology and composition, independent of the degree of stenosis, are important in the risk stratification of carotid atherosclerotic disease. This finding raises the question as to whether current guidelines are adequate or if they should be updated with new evidence, including imaging for plaque phenotyping, risk stratification, and clinical decision-making in addition to the degree of stenosis. To further this discussion, this roadmap consensus article defines the limits of luminal imaging and highlights the current evidence supporting the role of plaque imaging. Furthermore, we identify gaps in current knowledge and suggest steps to generate high-quality evidence, to add relevant information to guidelines currently based on the quantification of stenosis.AHAAmerican Heart AssociationIPHintraplaque hemorrhageLRNClipid-rich necrotic core