RT Journal Article
SR Electronic
T1 Degeneration of the Mid-Cingulate Cortex in Amyotrophic Lateral Sclerosis Detected In Vivo with MR Spectroscopy
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 403
OP 407
DO 10.3174/ajnr.A2289
VO 32
IS 2
A1 N. Sudharshan
A1 C. Hanstock
A1 B. Hui
A1 T. Pyra
A1 W. Johnston
A1 S. Kalra
YR 2011
UL http://www.ajnr.org/content/32/2/403.abstract
AB BACKGROUND AND PURPOSE: Various lines of evidence implicate cerebral involvement beyond the motor cortex in ALS, including the cingulate gyrus and the thalamus. The purpose of this study was to assess neurodegeneration in these regions in vivo by using MRSI. MATERIALS AND METHODS: Fourteen patients with ALS and 14 healthy controls underwent MRSI by using a coronal acquisition scheme. The NAA/Cho ratio was quantified in the MCC, thalamus, and motor cortex (PCG). RESULTS: NAA/Cho was reduced in the MCC in patients with ALS compared with the controls (P = .0004). There was no difference in NAA/Cho in the thalamus (P = .59). We also found a strong correlation of NAA/Cho among the PCG, MCC, and the thalamus in controls, which was absent in patients with ALS. CONCLUSIONS: Neurodegeneration beyond the motor cortex is present in the MCC in ALS. The significant correlation of NAA/Cho among the PCG, MCC, and the thalamus in healthy subjects likely reflects the neuronal connectivity among these regions. The loss of these relationships in patients with ALS suggests that such connectivity is not responsible for the pattern of degeneration in these regions. ALSamyotrophic lateral sclerosisALSFRSALS Functional Rating Scale11Ccarbon-11ChocholineCMAcingulate motor areasCrcreatineDTIdiffusion tensor imagingFDGfluorodeoxyglucosefMRIfunctional MR imagingFTDfrontotemporal dementiaFTLDfrontotemporal lobar degenerationGABAAgamma-aminobutyric acid type A receptorLMNlower motor neuronsMCCmid-cingulate cortexMRSIMR spectroscopic imagingNAAN-acetylaspartatePCGprecentral gyrusPETpositron-emission tomographyTDP-43TAR DNA−binding protein 43THALthalamusUMNupper motor neurons