PT  - JOURNAL ARTICLE
AU  - M.A. Essibayi
AU  - G. Lanzino
AU  - W. Brinjikji
TI  - Safety and Efficacy of the Woven EndoBridge Device for Treatment of Ruptured Intracranial Aneurysms: A Systematic Review and Meta-analysis
AID  - 10.3174/ajnr.A7174
DP  - 2021 Sep 01
TA  - American Journal of Neuroradiology
PG  - 1627--1632
VI  - 42
IP  - 9
4099  - http://www.ajnr.org/content/42/9/1627.short
4100  - http://www.ajnr.org/content/42/9/1627.full
SO  - Am. J. Neuroradiol.2021 Sep 01; 42
AB  - BACKGROUND: The Woven EndoBridge device has been increasingly used to treat wide-neck aneurysms, particularly ruptured ones.PURPOSE: Our aim was to investigate the safety and efficacy of the Woven EndoBridge device in the treatment of ruptured intracranial aneurysms.DATA SOURCES: All studies evaluating the outcomes of Woven EndoBridge device use in the treatment of ruptured intracranial aneurysms from inception through 2020 were searched on Ovid Evidence-Based Medicine Reviews, EMBASE, MEDLINE, Scopus, and the Web of Science Core Collection.STUDY SELECTION: Eighteen studies encompassing 487 patients with 496 ruptured aneurysms treated with the Woven EndoBridge device were included.DATA ANALYSIS: We studied rates of rerupture and retreatment, angiographic outcomes at the last follow-up point, complications, and mortality rates. Data were collected on anticoagulation and antiplatelet use. Meta-analysis was performed using the random effects model.DATA SYNTHESIS: The rate of late rebleeding was 1.1% (95% CI, 0.1%–2.1%). The treatment-related perioperative complication rate and the overall clinical complication rate were 13.2% (95% CI, 9.2%–17.2%) and 3.2% (95% CI, 1.6%–4.7%), respectively. Thirteen hemorrhagic (2%; 95% CI, 0.8%–3.3%) and 41 thromboembolic (6.8%; 95% CI, 4.6%–9%) complications occurred. Favorable clinical outcomes were achieved in 85% of patients. Procedure-related mortality and overall mortality rates were 2.1% (95% CI, 0.8%–3.3%) and 11.5% (95% CI, 7%–16%), respectively. At last follow-up, an adequate occlusion rate was 87.3% (95% CI, 82.1%–92.4%) and the retreatment rate was 5.1% (95% CI, 3%–7.3%).LIMITATIONS: Our meta-analysis is limited by selection bias and high heterogeneity.CONCLUSIONS: This meta-analysis demonstrated the safety and efficacy of the Woven EndoBridge device in the management of ruptured aneurysms, but further studies are needed.APTantiplatelet therapy