TY - JOUR T1 - Identification and Clinical Impact of Multiple Sclerosis Cortical Lesions as Assessed by Routine 3T MR Imaging JF - American Journal of Neuroradiology JO - Am. J. Neuroradiol. SP - 515 LP - 521 DO - 10.3174/ajnr.A2340 VL - 32 IS - 3 AU - A. Mike AU - B.I. Glanz AU - P. Hildenbrand AU - D. Meier AU - K. Bolden AU - M. Liguori AU - E. Dell'Oglio AU - B.C. Healy AU - R. Bakshi AU - C.R.G. Guttmann Y1 - 2011/03/01 UR - http://www.ajnr.org/content/32/3/515.abstract N2 - BACKGROUND AND PURPOSE: Histopathologic studies have reported widespread cortical lesions in MS; however, in vivo detection by using routinely available pulse sequences is challenging. We investigated the relative frequency and subtypes of cortical lesions and their relationships to white matter lesions and cognitive and physical disability. MATERIALS AND METHODS: Cortical lesions were identified and classified on the basis of concurrent review of 3D FLAIR and 3D T1-weighted IR-SPGR 3T MR images in 26 patients with MS. Twenty-five patients completed the MACFIMS battery. White matter lesion volume, cortical lesion number, and cortical lesion volume were assessed. RESULTS: Overall, 249 cortical lesions were detected. Cortical lesions were present in 24/26 patients (92.3%) (range per patient, 0–30; mean, 9.6 ± 8.8). Most (94.4%, n = 235) cortical lesions were classified as mixed cortical-subcortical (type I); the remaining 5.6% (n = 14) were classified as purely intracortical (type II). Subpial cortical lesions (type III) were not detected. White matter lesion volume correlated with cortical lesion number and cortical lesion volume (rS = 0.652, rS = 0.705, respectively; both P < .001). After controlling for age, depression, and premorbid intelligence, we found that all MR imaging variables (cortical lesion number, cortical lesion volume, white matter lesion volume) correlated with the SDMT score (R2 = 0.513, R2 = 0.449, R2 = 0.418, respectively; P < .014); cortical lesion number also correlated with the CVLT-II scores (R2 = 0.542–0.461, P < .043). The EDSS scores correlated with cortical lesion number and cortical lesion volume (rS = 0.472, rS = 0.404, respectively; P < .05), but not with white matter lesion volume. CONCLUSIONS: Our routinely available imaging method detected many cortical lesions in patients with MS and was useful in their precise topographic characterization in the context of the gray matter−white matter junction. Routinely detectable cortical lesions were related to physical disability and cognitive impairment. BVMT-RBrief Visuospatial Memory Test-RevisedCES-DCenter for Epidemiologic Studies Depression ScaleCLNcortical lesion numberCLVcortical lesion volumeCOWATControlled Oral Word Association TestCVLT-IICalifornia Verbal Learning Test, second editionD-KEFSDelis-Kaplan Executive Function System Sorting TestEDSSExpanded Disability Status ScaleFLAIRfluid-attenuated inversion recoveryIR-SPGRinversion recovery spoiled gradient recalledJLOJudgment of Line Orientation TestMACFIMSMinimal Assessment of Cognitive Function in Multiple SclerosisMaxmaximumMinminimumMSmultiple sclerosisN/Anot applicableNAARTNorth American Adult Reading TestPASATPaced Auditory Serial Addition TestRRrelapsing-remittingrSSpearman correlation coefficientSDMTSymbol Digit Modalities TestSPsecondary-progressiveSt βpartial regression coefficient for standardized dataTLVtotal lesion volume = CLV + WMLVWMLVwhite matter lesion volume ER -