PT - JOURNAL ARTICLE AU - S.M. Riad AU - H. Hathout AU - J.C. Huang TI - High T2 Signal in Primary Lateral Sclerosis Supports the Topographic Distribution of Fibers in the Corpus Callosum: Assessing Disease in the Primary Motor Segment AID - 10.3174/ajnr.A2067 DP - 2011 Apr 01 TA - American Journal of Neuroradiology PG - E61--E64 VI - 32 IP - 4 4099 - http://www.ajnr.org/content/32/4/E61.short 4100 - http://www.ajnr.org/content/32/4/E61.full SO - Am. J. Neuroradiol.2011 Apr 01; 32 AB - SUMMARY: PLS is a disease of the UMN, distinguished from ALS in prognosis and absence of LMN signs. We present, to our knowledge, the first conventional MR imaging visualization of the callosal motor segment, a concept previously supported by primate models, electrophysiologic studies, and postmortem examinations. Modification of the Witelson topographic scheme of the CC is supported by MR tractography. On the basis of 2 cases of PLS, we present conventional imaging confirmation of the revised topographic scheme of fiber distribution across the CC. ALSamyotrophic lateral sclerosisCCcorpus callosumCSTcorticospinal tractDTIdiffusion tensor imagingFAfractional anisotropyFLAIRfluid-attenuated inversion recoveryLMNlower motor neuronPLSprimary lateral sclerosisUMNupper motor neuron