TY - JOUR T1 - Frequency and Location of Dilated Virchow-Robin Spaces in Elderly People: A Population-Based 3D MR Imaging Study JF - American Journal of Neuroradiology JO - Am. J. Neuroradiol. SP - 709 LP - 713 DO - 10.3174/ajnr.A2366 VL - 32 IS - 4 AU - Y.-C. Zhu AU - C. Dufouil AU - B. Mazoyer AU - A. SoumarĂ© AU - F. Ricolfi AU - C. Tzourio AU - H. Chabriat Y1 - 2011/04/01 UR - http://www.ajnr.org/content/32/4/709.abstract N2 - BACKGROUND AND PURPOSE: dVRS have been previously associated with aging and cerebrovascular diseases. However, little is known about their prevalence and topographic distribution in the general elderly population. MATERIALS AND METHODS: dVRS were evaluated by using high-resolution 3D MR imaging in 1826 subjects enrolled in the 3C-Dijon MR imaging study. On T1-weighted MR imaging, dVRS were detected according to 3D imaging criteria and rated by using 4-level severity scores based in the BG or in the WM. The number and anatomic location of large dVRS (≥3 mm) were recorded. RESULTS: dVRS were observed in the BG or WM in every subject. The severity of dVRS was significantly associated with higher age in both the BG and WM, whereas sex was related to the severity of dVRS only in the BG. Large dVRS were detected in 33.2% of participants. Status cribrosum was found in 1.3% of participants. dVRS were also highly prevalent within the hippocampus (44.5%) and hypothalamus (11.6%). CONCLUSIONS: dVRS are always detected in the BG or WM in elderly people, and large dVRS are also prevalent. The topographic distribution of dVRS is not uniform within the brain and may depend on anatomic or pathologic characteristics interacting with aging and sex. BGbasal ganglia3C3 cityCADASILcerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathyCMAcortical medullary arteriesdVRSdilated Virchow-Robin spacesINSERMFrench Institute of Health and Medical ResearchLSAlenticulostriate arteriesUMRMixed Unit of ResearchWMwhite matter ER -