RT Journal Article
SR Electronic
T1 Voxelwise Assessment of the Regional Distribution of Damage in the Brains of Patients with Multiple Sclerosis and Fatigue
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 874
OP 879
DO 10.3174/ajnr.A2412
VO 32
IS 5
A1 G. Riccitelli
A1 M.A. Rocca
A1 C. Forn
A1 B. Colombo
A1 G. Comi
A1 M. Filippi
YR 2011
UL http://www.ajnr.org/content/32/5/874.abstract
AB BACKGROUND AND PURPOSE: Fatigue affects up to 90% of patients with MS. We assessed the regional distribution of lesions and atrophy of the normal-appearing WM and GM in patients with RRMS with fatigue compared with HC and patients with similar characteristics, but without fatigue. MATERIALS AND METHODS: From 14 patients with RRMS without fatigue, 10 with RRMS with fatigue, and 14 HC, we acquired brain dual-echo and high-resolution T1-weighted scans. Voxel-wise distributions of GM, WM damage, and T2 lesions were compared between patients with fatigued and nonfatigued MS by using SPM5 software. We report results at P < .05, FWE corrected. RESULTS: T2 lesion distribution and regional WM atrophy did not differ between patients with fatigued and nonfatigued MS. Compared with HC, patients with MS had significant WM atrophy in the posterior part of the corpus callosum and significant GM atrophy of the left superior frontal sulcus, left precentral gyrus, posterior cingulate cortex, right thalamus, and left middle frontal gyrus. No additional areas of atrophy were found in patients with nonfatigued MS compared with HC, whereas patients with fatigued MS also had atrophy of the left central sulcus. Atrophy in the left central sulcus and the precentral gyrus was more severe in patients with fatigued versus nonfatigued MS. In patients with MS, significant correlations were found between fatigue severity and GM atrophy in the left precentral gyrus (r = −0.73, P < .0001 uncorrected). CONCLUSIONS: Atrophy of the primary sensorimotor area is likely to contribute to MS-related fatigue. DARTELDiffeomorphic Anatomical Registration Through Exponentiated Lie AlgebraEDSSExpanded Disability Status ScaleFSSFatigue Severity ScaleFWEfamily-wise errorGMgray matterGMVgray matter volumeHChealthy controlsICVintracranial volumeLPMlesion probability mapLVlesion volumeMNIMontreal Neurologic InstituteMPRAGEmagnetization-preparation rapid gradient echoMSmultiple sclerosisNBVnormalized brain volumeRRMSrelapsing-remitting MSSPMstatistical parametric mappingWMwhite matterWMVwhite matter volume