PT  - JOURNAL ARTICLE
AU  - W.S. Tae
AU  - S.S. Kim
AU  - K.U. Lee
AU  - E.C. Nam
AU  - J.W. Choi
AU  - J.I. Park
TI  - Hippocampal Shape Deformation in Female Patients with Unremitting Major Depressive Disorder
AID  - 10.3174/ajnr.A2367
DP  - 2011 Apr 01
TA  - American Journal of Neuroradiology
PG  - 671--676
VI  - 32
IP  - 4
4099  - http://www.ajnr.org/content/32/4/671.short
4100  - http://www.ajnr.org/content/32/4/671.full
SO  - Am. J. Neuroradiol.2011 Apr 01; 32
AB  - BACKGROUND AND PURPOSE: The hippocampal atrophy of MDD has been known, but the region shape contractions of the hippocampus in MDD were inconsistent. Spheric harmonic shape analysis was applied to the hippocampus in female patients with unremitting MDD to evaluate morphometric changes of the hippocampus. MATERIALS AND METHODS: Shape analysis was performed by using T1-weighted MR imaging in 21 female patients with MDD and 21 age- and sex-matched healthy controls. Manually segmented hippocampi were parameterized, and the point-to-point–based group difference was compared by using the Hotelling T-squared test. The partial correlation analyses were tested between clinical variables and shape changes. RESULTS: Both hippocampal volumes were small in patients with MDD compared with healthy controls, and the right hippocampal volume was negatively correlated with the number of episodes at marginal significance. Regional shape contractions were found in the ambient gyrus, basal hippocampal head, posterior subiculum, and dorsal hippocampus of the left hemisphere. The right hippocampus showed a similar pattern but was less atrophic compared with the left hippocampus. A negative correlation was found between the HDRS and shape deformation in the CA3, ambient gyrus, posterior subiculum, and gyrus fasciolaris of the left hippocampus. CONCLUSIONS: We showed atrophy and regional shape contractions in the hippocampi of patients with MDD, which were more dominant on the left side. The causes of hippocampal damage could be the hypersecretion of glucocorticoids contributing to neuronal death or the failing of adult neurogenesis in the dentate gyrus. AGambient gyrusANCOVAanalysis of covarianceApoeapolipoprotein EAvr. Surf.average statistic across the surfaceBDIBeck Depression InventoryCAcornu ammonisFDRfalse discovery rateHDRSHamilton Depression Rating ScaleICCintraclass correlation coefficientICVintracranial cavity volumeLHleft hippocampusMDDmajor depressive disorderN#the subject number of each healthy control subjectP#the subject number of each patient with MDDPDMpoint distribution modelRHright hippocampusSCIDStructured Clinical Interview for DSM-IVSPHARMspheric harmonic basis functionsSubsubiculumTFEturbo field echoVOIvolume of interest