TY - JOUR T1 - Apparent Diffusion Coefficients of Metabolites in Patients with MELAS Using Diffusion-Weighted MR Spectroscopy JF - American Journal of Neuroradiology JO - Am. J. Neuroradiol. SP - 898 LP - 902 DO - 10.3174/ajnr.A2395 VL - 32 IS - 5 AU - Z. Liu AU - D. Zheng AU - X. Wang AU - J. Zhang AU - S. Xie AU - J. Xiao AU - X. Jiang Y1 - 2011/05/01 UR - http://www.ajnr.org/content/32/5/898.abstract N2 - BACKGROUND AND PURPOSE: DW-MR spectroscopy can detect the diffusion coefficients of NAA, Cr, PCr, and Cho and can, therefore, provide some useful information. The aims of this study were to probe the mechanisms underlying the pathogenesis of MELAS and to see whether DW-MR spectroscopy is a useful technique for other diseases besides cerebral infarction. MATERIALS AND METHODS: Fifteen healthy volunteers and 10 patients with MELAS were enrolled in the study. All were scanned on a 3T whole-body MR imaging scanner. Fifteen ADCs of the singlet metabolites in the gray matter of the healthy subjects, 10 ADCs of the singlet metabolites in the lesions, and 8 ADCs of the singlet metabolites in the nonaffected areas were used in the statistical analysis, respectively. RESULTS: The metabolite ADCs of the nonaffected areas and the lesions in the patients were higher than those of the frontal gray matter in the healthy controls. There were significant differences between the metabolite ADCs of the nonaffected areas in patients and those in the healthy controls, and it was the same with the metabolite ADCs of the lesions and those of the healthy controls. CONCLUSIONS: The increased ADC values of the metabolites reveal that MELAS is a mitochondrial neuronopathy and involves the entire brain. DW-MR spectroscopy is a very useful noninvasive technique, which can show some valuable information that conventional MR imaging cannot display. Thus, it can be applied to brain diseases besides cerebral infarction. ADCapparent diffusion coefficientATPadenosine triphosphateChocholineCrcreatineDWdiffusion-weightedDWIdiffusion-weighted imagingFLAIRfluid-attenuated inversion recoveryMELASmitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodesNAAN-acetylaspartatePCrphosphocreatineVOIvolume of interest ER -