RT Journal Article
SR Electronic
T1 Mechanical Thrombectomy for Treatment of Cerebral Venous Sinus Thrombosis in Vaccine-Induced Immune Thrombotic Thrombocytopenia
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 98
OP 101
DO 10.3174/ajnr.A7381
VO 43
IS 1
A1 H.S. Chew
A1 S. Al-Ali
A1 B. Butler
A1 D. Rajapakse
A1 K. Nader
A1 S. Chavda
A1 S. Lamin
YR 2022
UL http://www.ajnr.org/content/43/1/98.abstract
AB SUMMARY: Reports of a rare form of cerebral venous sinus thrombosis with profound thrombocytopenia have emerged following introduction of the adenovirus-vectored coronavirus disease 2019 (COVID-19) vaccines. Between March and June 2021, seven cases of refractory vaccine-induced immune thrombotic thrombocytopenia were referred to our institution for mechanical thrombectomy. The condition of 1 patient deteriorated during interhospital transfer, and the remaining 6 underwent successful recanalization. No procedure-related adverse events were reported. At the time of this writing, 3 patients have been discharged with a good functional outcome (mRS 0–1), one required rehabilitation for mild dysarthria and vocal cord palsy (mRS 3), and 2 have died due to severe mass effect. Our anecdotal experience suggests that endovascular therapy may be safe and effective in reducing thrombus burden in selected cases of postvaccination cerebral venous sinus thrombosis.COVID-19coronavirus disease 2019CVSTcerebral venous sinus thrombosisHITheparin-induced thrombocytopeniaICHintracerebral hemorrhagePFplatelet factorVITTvaccine-induced immune thrombotic thrombocytopenia