PT  - JOURNAL ARTICLE
AU  - S. Albayram
AU  - S. Saip
AU  - Z.I. Hasiloglu
AU  - M. Teke
AU  - E. Ceyhan
AU  - M. Tutuncu
AU  - H. Selcuk
AU  - A. Kina
AU  - A. Siva
TI  - Evaluation of Parenchymal Neuro-Behçet Disease by Using Susceptibility-Weighted Imaging
AID  - 10.3174/ajnr.A2477
DP  - 2011 Jun 01
TA  - American Journal of Neuroradiology
PG  - 1050--1055
VI  - 32
IP  - 6
4099  - http://www.ajnr.org/content/32/6/1050.short
4100  - http://www.ajnr.org/content/32/6/1050.full
SO  - Am. J. Neuroradiol.2011 Jun 01; 32
AB  - BACKGROUND AND PURPOSE: Neurologic involvement in Behçet disease, also known as NBD, is one of the most devastating manifestations of the disease. The precise pathologic mechanism of parenchymal NBD lesions has not been established. We evaluated lesion characteristics and probable venous hemorrhage in parenchymal NBD by using SWI, and we compared the imaging results with conventional MR imaging sequences. MATERIALS AND METHODS: We performed cranial MR imaging by using a 1.5T scanner in 23 patients with a definitive diagnosis of parenchymal NBD. We compared the proportion of lesion detection and the performance of hemorrhagic detection with the T2 FSE, T2*GE, and SWI magnitude, and SWI mIP by using the χ2 test. RESULTS: The proportion of lesion detection with both SWI magnitude and SWI MinMIP was significantly larger than that with T2*GE. The proportions of lesion detection among all other pairs of methods were not significantly different according to the corresponding P value (χ2 = 17.4929, df = 3, P = .0006). Proportions of hypointense hemorrhagic lesions with T2 FSE and T2*GE were not significantly different, and likewise for the proportions of hypointense hemorrhagic lesions with SWI magnitude and SWI mIP. In contrast, the proportions of hypointense hemorrhagic lesions with SWI magnitude and SWI mIP were significantly larger than that with T2 FSE and T2*GE (χ2 = 108.5396, df = 3, P < .0001). CONCLUSIONS: Most of the lesions in parenchymal NBD were found to be hemorrhagic with SWI, supporting the proposed venous theory in pathology. In addition, compared with T2 FSE and T2*GE sequences, SWI was more successful in the determination of widespread involvement of the disease, particularly in nonchronic cases. BDBehçet diseaseBSAbrain stem atrophyCCcorpus callosumCVcollateral veinmIPminimum intensity projectionNBDneuro-Behçet diseasePVSprominent venous structureSWIsusceptibility-weighted imagingT2 FSET2-weighted fast spin-echoT2*GET2*-weighted gradient-echoTSVthalamostriate vein