PT  - JOURNAL ARTICLE
AU  - F.R. Miese
AU  - F.R. Schuster
AU  - K. Pierstorff
AU  - M. Karenfort
AU  - H.J. Laws
AU  - A. Borkhardt
AU  - A. Saleh
TI  - Magnetization Transfer Imaging Provides No Evidence of Demyelination in Methotrexate-Induced Encephalopathy
AID  - 10.3174/ajnr.A2181
DP  - 2011 Jun 01
TA  - American Journal of Neuroradiology
PG  - E110--E112
VI  - 32
IP  - 6
4099  - http://www.ajnr.org/content/32/6/E110.short
4100  - http://www.ajnr.org/content/32/6/E110.full
SO  - Am. J. Neuroradiol.2011 Jun 01; 32
AB  - SUMMARY: Subacute MTX-induced encephalopathy is characterized by an abrupt onset of focal neurologic deficits within days after intrathecal or systemic therapy. Demyelination is one proposed mechanism. We describe the neuroimaging features of 2 patients with clinical symptoms of subacute encephalopathy after intrathecal and systemic MTX therapy. DWI showed restricted diffusion, indicating cytotoxic edema. MTI yielded no evidence of demyelination in either patient because there was no loss of MTR in areas of restricted diffusion. ADCapparent diffusion coefficientALLacute lymphoblastic leukemiaDWIdiffusion-weighted imagingITintrathecalIVintravenousMTImagnetization transfer imagingMTRmagnetization transfer ratioMTXmethotrexate