RT Journal Article
SR Electronic
T1 Candidate Biomarkers of Extravascular Extracellular Space: A Direct Comparison of Apparent Diffusion Coefficient and Dynamic Contrast-Enhanced MR Imaging—Derived Measurement of the Volume of the Extravascular Extracellular Space in Glioblastoma Multiforme
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 549
OP 553
DO 10.3174/ajnr.A1844
VO 31
IS 3
A1 S.J. Mills
A1 C. Soh
A1 C.J. Rose
A1 S. Cheung
A1 S. Zhao
A1 G.J.M. Parker
A1 A. Jackson
YR 2010
UL http://www.ajnr.org/content/31/3/549.abstract
AB BACKGROUND AND PURPOSE: ADC measurements have been shown to have an inverse relationship with tumor cell density. DCE-MR imaging modeling techniques can produce a measurement of the ve, which would also be expected to have an inverse relationship with cell density. The objective of this study was to test the hypothesis that areas of increased cellularity, and therefore low ADC, would be expected to have a small EES (low ve). MATERIALS AND METHODS: Nineteen patients with GBM were recruited. All imaging was performed before surgery on a 3T MR imaging scanner. Imaging included diffusion tensor imaging, T1-weighted DCE-MR imaging, and anatomic sequences. Tumor VOIs were defined on the anatomic images and modified to contain only enhancing voxels. Parametric maps of ADC and ve were generated. Statistical analysis of ADC and ve was performed on both a voxel-by-voxel basis and comparison of median values. RESULTS: No correlation was demonstrated between ADC and ve in either a voxel-by-voxel analysis or comparison of median values (P = .124). CONCLUSIONS: This study failed to demonstrate a correlation between ADC and ve. This is important because it suggests that though the mechanisms underlying these parameters are theoretically similar, they actually reflect different aspects of tumor microenvironment. Consequently ADC and ve should be considered to provide independent information about the properties of the EES. ADCapparent diffusion coefficientDCE-MRdynamic contrast-enhanced MRDWIdiffusion-weighted imagingEESextravascular extracellular spaceFFEfast-field echoFLIRTFMRIB Linear Image Registration ToolFSLFMRIB Software LibraryFMRIBFunctional Magnetic Resonance Imaging of the BrainGBMglioblastoma multiformeIAUCinitial area under the concentration curvemaxmaximumminminimumNSFnephrogenic systemic fibrosisvevolume of the extravascular extracellular space per unit volumeVOIvolume of interest