%0 Journal Article %A H. Hyare %A J. Thornton %A J. Stevens %A S. Mead %A P. Rudge %A J. Collinge %A T.A. Yousry %A H.R. Jäger %T High-b-Value Diffusion MR Imaging and Basal Nuclei Apparent Diffusion Coefficient Measurements in Variant and Sporadic Creutzfeldt-Jakob Disease %D 2010 %R 10.3174/ajnr.A1860 %J American Journal of Neuroradiology %P 521-526 %V 31 %N 3 %X BACKGROUND AND PURPOSE: DWI using a standard b-value of 1000s/mm2 has emerged as the most sensitive sequence for the diagnosis of CJD. The purpose of this study was to investigate whether DWI at a high b-value (b = 3000 s/mm2) and ADC measurements in the basal nuclei improve the diagnosis of vCJD and sCJD compared with visual assessment of DWI at a standard b-value (b = 1000 s/mm2). MATERIALS AND METHODS: Eight patients with vCJD, 9 patients with sCJD, and 5 healthy volunteers underwent DWI at b = 1000 s/mm2, and 5 vCJD patients, 4 sCJD patients, and 1 growth hormone-related CJD patient underwent DWI at b = 3000 s/mm2. Two consultant neuroradiologists performed a visual comparison of the b = 1000 and b = 3000 images. Mean MR SI and ADC values were determined for C, P, and DM thalamus ROIs bilaterally at each b-value. SI ratios for each ROI relative to white matter were calculated. RESULTS: In 9 out of 10 patients, the higher b-value images were more sensitive to SI change, particularly in cortex and thalamus, with higher SI ratios at b = 3000 in the DM thalamus. For sCJD at b = 1000, we found significantly lower ADC values in the C and P compared with controls (mean C ADC = 587.3 ± 84.7 mm2/s in sCJD patients versus 722.7 ± 16.6 mm2/s in controls; P = .007), and at b = 3000, the differences were more pronounced. In comparison, in vCJD at b = 1000, ADC values were elevated in the Pu (mean Pu ADC = 837.6 ± 33.0 mm/s2 in vCJD patients versus 748.0 ± 17.3 mm/s2 in controls; P < .001) but failed to reach significance at b = 3000. CONCLUSIONS: Our results demonstrate that b = 3000 DWI, being more sensitive to slowly diffusing tissue water, is more sensitive to pathology in sCJD than is conventional DWI. High-b-value DWI increases confidence in the radiologic diagnosis of human prion disease. ADCapparent diffusion coefficientCcaudateDMdorsomedialDWIdiffusion-weighted imagingFLAIRfluid-attenuated inversion recoveryFWMfrontal white matterPputamenPupulvinarROIregion of interestsCJDsporadic Creutzfeldt-Jakob DiseaseSIsignal intensitySPsuperior ponsvCJDvariant Creutzfeldt-Jakob Disease %U https://www.ajnr.org/content/ajnr/31/3/521.full.pdf