TY - JOUR T1 - Methadone-Induced Toxic Leukoencephalopathy: MR Imaging and MR Proton Spectroscopy Findings JF - American Journal of Neuroradiology JO - Am. J. Neuroradiol. SP - 565 LP - 566 DO - 10.3174/ajnr.A1889 VL - 31 IS - 3 AU - R.A. Salgado AU - P.G. Jorens AU - I. Baar AU - P. Cras AU - G. Hans AU - P.M. Parizel Y1 - 2010/03/01 UR - http://www.ajnr.org/content/31/3/565.abstract N2 - SUMMARY: We report the clinical, MR imaging, and proton MR spectroscopy findings in a middle-aged woman with proved methadone-induced toxic leukoencephalopathy. The imaging characteristics of this unusual condition have been reported only rarely in the medical literature. We show that the imaging findings in methadone-induced toxic leukoencephalopathy are similar, though not identical, to previously reported cases of neurologic deterioration due to heroin inhalation. ChocholineCrcreatineFLAIRfluid-attenuated inversion recoveryNAAN-acetylaspartate ER -